Hyperinsulinaemia, hyperaminoacidaemia and post-exercise muscle anabolism: the search for the optimal recovery drink

Br J Sports Med. 2006 Nov;40(11):900-5. doi: 10.1136/bjsm.2006.030031. Epub 2006 Sep 1.


Dietary supplements and other ergogenic aids are popular among athletes. Recent studies have shown that nutritional mixtures containing protein hydrolysates, added leucine, and high-glycaemic carbohydrates greatly augment insulin secretion compared with high-glycaemic carbohydrates only. When post-exercise hyperinsulinaemia is supported by hyperaminoacidaemia induced by protein hydrolysate and leucine ingestion, net protein deposition in muscle should occur. Thus, consumption of post-exercise recovery drinks containing these nutrients in conjunction with appropriate resistance training may lead to increased skeletal muscle hypertrophy and strength. However, the long-term effects on body composition and exercise performance remain to be determined.

Publication types

  • Review

MeSH terms

  • Amino Acids / blood*
  • Amino Acids / pharmacology
  • Dietary Carbohydrates / administration & dosage*
  • Dietary Supplements*
  • Exercise / physiology*
  • Humans
  • Insulin / blood*
  • Insulin / metabolism
  • Insulin Secretion
  • Leucine / pharmacology
  • Muscle, Skeletal / metabolism*
  • Protein Hydrolysates / pharmacology
  • Sports / physiology*


  • Amino Acids
  • Dietary Carbohydrates
  • Insulin
  • Protein Hydrolysates
  • Leucine