Mechanisms of disease: immunopathogenesis of celiac disease

Nat Clin Pract Gastroenterol Hepatol. 2006 Sep;3(9):516-25. doi: 10.1038/ncpgasthep0582.


Celiac disease is a genetic inflammatory disorder with autoimmune components that is induced by the ingestion of dietary gluten. Refractory sprue and enteropathy-associated T-cell lymphoma are rare but distinctive complications of the disease. Although the importance of the adaptive immune response to gluten has been well established, observations now also point towards a central role for the gluten-induced innate stress response in the pathogenesis of celiac disease and its malignant complications.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Celiac Disease / genetics
  • Celiac Disease / immunology*
  • Celiac Disease / physiopathology
  • Clinical Trials as Topic
  • GTP-Binding Proteins
  • Gliadin / immunology
  • Gliadin / metabolism
  • HLA-DQ Antigens / genetics
  • HLA-DQ Antigens / metabolism
  • Humans
  • Intestinal Mucosa / immunology
  • Transglutaminases / genetics
  • Transglutaminases / metabolism


  • HLA-DQ Antigens
  • HLA-DQ2 antigen
  • HLA-DQ8 antigen
  • Gliadin
  • transglutaminase 2
  • Transglutaminases
  • GTP-Binding Proteins