Accelerated atherosclerosis in pre-menopausal female patients with rheumatoid arthritis

Rheumatol Int. 2006 Dec;27(2):119-23. doi: 10.1007/s00296-006-0176-6. Epub 2006 Sep 5.

Abstract

Increased mortality due to cardiovascular disease in rheumatoid arthritis (RA) patients was reported. Using B-mode ultrasonography we compared intima-media thickness (IMT) and plaque occurrence (indicators of asymptomatic atherosclerosis) in the carotid arteries in 70 pre-menopausal, female RA patients and 40 controls. Correlations with different risk factors were evaluated. The IMT values were higher in RA patients (0.59 mm vs. 0.47 mm, P < 0.0001) and they had more plaques (P = 0.023). In RA patients higher levels of sensitive CRP (P < 0.0001), ICAM (P < 0.0001), VCAM (P < 0.0001), IL-2 (P < 0.001), IL-6 (P = 0.009) and TNF-alfa (P < 0.01) were found. A correlation between IMT and triglycerides (P = 0.018) and a negative correlation between IMT and HDL cholesterol (P = 0.037) were found. With multiple regression analysis the association between IMT and sensitive CRP (P = 0.027) and presence of plaques and apolipoprotein B (P = 0.028) was established. The results indicate that even pre-menopausal, female RA patients had accelerated atherosclerosis. Chronic systemic inflammation may play an important role in atherogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Arthritis, Rheumatoid / complications*
  • Atherosclerosis / complications*
  • Atherosclerosis / physiopathology
  • Biomarkers
  • C-Reactive Protein / immunology
  • Carotid Arteries / diagnostic imaging
  • Carotid Arteries / pathology*
  • Case-Control Studies
  • Female
  • Humans
  • Inflammation / complications
  • Middle Aged
  • Premenopause*
  • Risk Factors
  • Tunica Intima / pathology*
  • Ultrasonography

Substances

  • Biomarkers
  • C-Reactive Protein