Neurotransmitters and neuromodulators in the basal ganglia

Trends Neurosci. 1990 Jul;13(7):244-54. doi: 10.1016/0166-2236(90)90104-i.


The basal ganglia have become a focus for work on neurotransmitter interactions in the brain. These structures contain a remarkable diversity of neuroactive substances, organized into functional subsystems that have unique developmental histories and vulnerabilities in neurodegenerative diseases. A new view of the basal ganglia is emerging on the basis of this neurochemical heterogeneity, suggesting that dynamic regulation of transmitter expression may be a key to extrapyramidal function.

Publication types

  • Review

MeSH terms

  • Animals
  • Basal Ganglia / metabolism
  • Basal Ganglia / physiology*
  • Corpus Striatum / physiology
  • Gene Expression Regulation
  • Humans
  • Neural Pathways / physiology
  • Neuropeptides / genetics
  • Neuropeptides / physiology
  • Neurotransmitter Agents / physiology*


  • Neuropeptides
  • Neurotransmitter Agents