DSD-1-Proteoglycan/Phosphacan and receptor protein tyrosine phosphatase-beta isoforms during development and regeneration of neural tissues

Adv Exp Med Biol. 2006;557:25-53. doi: 10.1007/0-387-30128-3_3.

Abstract

Interactions between neurons and glial cells play important roles in regulating key events of development and regeneration of the CNS. Thus, migrating neurons are partly guided by radial glia to their target, and glial scaffolds direct the growth and directional choice of advancing axons, e.g., at the midline. In the adult, reactive astrocytes and myelin components play a pivotal role in the inhibition of regeneration. The past years have shown that astrocytic functions are mediated on the molecular level by extracellular matrix components, which include various glycoproteins and proteoglycans. One important, developmentally regulated chondroitin sulfate proteoglycan is DSD-1-PG/phosphacan, a glial derived proteoglycan which represents a splice variant of the receptor protein tyrosine phosphatase (RPTP)-beta (also known as PTP-zeta). Current evidence suggests that this proteoglycan influences axon growth in development and regeneration, displaying inhibitory or stimulatory effects dependent on the mode of presentation, and the neuronal lineage. These effects seem to be mediated by neuronal receptors of the Ig-CAM superfamily.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Line
  • Central Nervous System* / cytology
  • Central Nervous System* / pathology
  • Central Nervous System* / physiology
  • Chondroitin Sulfate Proteoglycans / genetics
  • Chondroitin Sulfate Proteoglycans / metabolism*
  • Chondroitin Sulfates / genetics
  • Chondroitin Sulfates / metabolism*
  • Extracellular Matrix / metabolism
  • Humans
  • Ligands
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Neurons / cytology
  • Neurons / physiology
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism*
  • Protein Tyrosine Phosphatases / genetics
  • Protein Tyrosine Phosphatases / metabolism*
  • Receptor-Like Protein Tyrosine Phosphatases, Class 5
  • Regeneration / physiology*
  • Transforming Growth Factor beta / metabolism

Substances

  • Chondroitin Sulfate Proteoglycans
  • DSD-1-proteoglycan
  • Ligands
  • Nerve Tissue Proteins
  • Protein Isoforms
  • Transforming Growth Factor beta
  • Chondroitin Sulfates
  • PTPRZ1 protein, human
  • Protein Tyrosine Phosphatases
  • Receptor-Like Protein Tyrosine Phosphatases, Class 5