Association between the functional polymorphism in the matrix metalloproteinase-7 promoter and susceptibility to adult astrocytoma

Brain Res. 2006 Nov 6;1118(1):6-12. doi: 10.1016/j.brainres.2006.08.007. Epub 2006 Sep 7.


To study the association between the A to G transition at the -181-bp position in the promoter of matrix metalloproteinase-7 gene (MMP-7-181A/G) and susceptibility to adult astrocytoma, the MMP-7-181A/G polymorphism was genotyped by PCR-RFLP analysis among 221 adult astrocytoma patients and 366 healthy controls in a population of northern China. The result showed that the overall distribution of the MMP-7 genotypes among astrocytoma patients and healthy controls was significantly different (P<0.001). Compared with the A/A genotype, the G/G genotype significantly increased the risk to the development of astrocytoma (age and gender adjusted OR=2.77, 95% CI=1.27-6.02), while the MMP-7 A/G genotype only marginally increased the risk of developing this cancer (age and gender adjusted OR=1.66, 95% CI=0.99-2.84). Stratification analysis showed that the G/G genotype significantly increased the risk of astrocytoma only among male subjects (age adjusted OR=3.24, 95% CI=1.12-9.41) and individuals younger than 45 years (age and gender adjusted OR=3.16, 95% CI=1.09-9.16). When stratified by histological grades, a significant higher risk for developing grade II astrocytoma was observed among individuals harboring the A/G genotype (age and gender adjusted OR=2.06, 95% CI=1.05-4.05), while an about 3-fold elevation of risk to develop grades II, III, and IV astrocytomas was observed among individuals with the G/G genotype. The present result, for the first time, suggested that the MMP-7-181A/G polymorphism might be associated with the susceptibility to adult astrocytoma.

MeSH terms

  • Adult
  • Age Factors
  • Astrocytoma / enzymology
  • Astrocytoma / genetics*
  • Astrocytoma / physiopathology
  • Biomarkers, Tumor / genetics
  • Brain Neoplasms / enzymology
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / physiopathology
  • DNA Mutational Analysis
  • Female
  • Gene Frequency
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genotype
  • Humans
  • Male
  • Matrix Metalloproteinase 7 / genetics*
  • Matrix Metalloproteinase 7 / metabolism
  • Middle Aged
  • Polymorphism, Genetic / genetics*
  • Promoter Regions, Genetic / genetics*
  • Sex Factors


  • Biomarkers, Tumor
  • Genetic Markers
  • Matrix Metalloproteinase 7