ET-1 and ecNOS gene polymorphisms andsusceptibility to acute chest syndrome and painful vaso-occlusive crises in children with sickle cell anemia

Haematologica. 2006 Sep;91(9):1277-8.

Abstract

The association of endothelin 1 (ET-1) and endothelial constitutive nitric oxide synthase (ecNOS) gene polymorphisms (G5665T and T8002C, VNTR and T-786C respectively) with the occurrence of acute chest syndrome and painful vaso-occlusive crises was evaluated in homozygous SS children. This retrospective study reveals that ET-1 T8002 and ecNOS C-786 alleles are associated with, respectively, an increased and a decreased risk of acute chest syndrome.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anemia, Sickle Cell / complications*
  • Anemia, Sickle Cell / genetics*
  • Chest Pain / genetics
  • Child
  • Endothelin-1 / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Nitric Oxide Synthase Type III / genetics*
  • Pain
  • Polymorphism, Genetic
  • Vascular Diseases

Substances

  • Endothelin-1
  • Nitric Oxide Synthase Type III