Obstructive sleep apnoea inhibits the recovery of left ventricular function in patients with acute myocardial infarction

Eur Heart J. 2006 Oct;27(19):2317-22. doi: 10.1093/eurheartj/ehl219. Epub 2006 Sep 6.


Aims: It has been suggested that obstructive sleep apnoea syndrome (OSA) may be a direct cause of left ventricular (LV) systolic dysfunction. This study was designed to examine our hypothesis that OSA inhibits the recovery of LV function in patients with acute myocardial infarction (AMI).

Methods and results: Our 86 consecutive first-AMI patients underwent primary percutaneous coronary intervention (PCI). All patients underwent polysomnography and OSA was defined as an apnoea-hypoapnoea index (AHI) > or =15 events/h, of which more than 50% were obstructive. Left ventriculograms immediately after PCI and at 21 days were used to evaluate LV ejection fraction (LVEF), LV end-diastolic volume index, and regional wall motion (RWM) within the infarct area. OSA was observed in 37 patients (43%). All three indices of LV function after primary PCI were comparable between the two groups. Increases in LVEF and RWM during admission were significantly lower in OSA patients than those without OSA (delta LVEF: -0.3+/-9.6 vs. 7.4+/-7.2%, P < 0.001; delta RWM: 0.26+/-1.04 SD/chord vs. 1.16+/-1.20 SD/chord, P = 0.002). Multiple regression analysis showed that AHI correlated negatively with delta LVEF and delta RWM.

Conclusion: The novel finding is that OSA may inhibit the recovery of LV function in patients with AMI.

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary / methods
  • Continuous Positive Airway Pressure / methods
  • Female
  • Humans
  • Male
  • Myocardial Infarction / complications*
  • Myocardial Infarction / physiopathology
  • Myocardial Infarction / therapy
  • Polysomnography
  • Recovery of Function / physiology
  • Sleep Apnea, Obstructive / complications*
  • Sleep Apnea, Obstructive / physiopathology
  • Sleep Apnea, Obstructive / therapy
  • Ventricular Dysfunction, Left / etiology*
  • Ventricular Dysfunction, Left / therapy