Characterization of naturally occurring minor histocompatibility peptides including H-4 and H-Y

Science. 1990 Jul 20;249(4966):283-7. doi: 10.1126/science.1695760.


Minor histocompatibility (H) antigens can be peptides derived from cellular proteins that are presented on the cell surface by major histocompatibility complex (MHC) class I molecules. This is similar to viral antigens, because in both cases cytotoxic T lymphocytes (CTLs) recognize artificially produced peptides loaded on target cells. Naturally processed minor H peptides were found to be similar to those artificial CTL-epitopes, as far as size and hydrophobicity is concerned. The peptides studied were isolated from a transfectant that expressed a model CTL-defined antigen, beta-galactosidase, from male cells that express H-Y, which has been known operationally since 1955, and from cells that express H-4, known since 1961.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Epitopes / isolation & purification
  • Female
  • H-Y Antigen / analysis*
  • H-Y Antigen / immunology
  • Male
  • Mice
  • Mice, Inbred Strains
  • Minor Histocompatibility Antigens / analysis*
  • Minor Histocompatibility Antigens / immunology
  • Molecular Sequence Data
  • Peptides / chemical synthesis
  • Species Specificity
  • Spleen / immunology
  • T-Lymphocytes, Cytotoxic / immunology*


  • Epitopes
  • H-Y Antigen
  • Minor Histocompatibility Antigens
  • Peptides