Factors contributing to blood-brain barrier disruption following intracarotid injection of nonionic iodinated contrast medium for cerebral angiography: experimental study in rabbits

Radiat Med. 2006 Jun;24(5):321-6. doi: 10.1007/s11604-006-0030-5.


Purpose: This study was performed to investigate the role of injection methods and conditions under a fixed dose of radiographic contrast medium (CM) in respect to promoting blood-brain barrier (BBB) disruption.

Materials and methods: A total of 44 white rabbits (average body weight 2.7 +/- 0.4 kg) were used, and their carotid injection was performed with nonionic CM. The variables assessed for the carotid injections included the following: iodine content (300 or 150 mg I/ml), liquid temperature (37 degrees or 24 degrees C), and the injection time duration (1 or 30 s). The rabbits were divided into five groups. To evaluate BBB disruption, pre- and post-contrast-enhanced magnetic resonance (MR) studies were performed.

Results: Abnormal enhancement of the brain parenchyma in MRI was noted in only one group, which consisted of high-iodine concentration CM injected at a low temperature over a short injection interval. Statistically significant increased values for the percentage of relative enhancement (RE%) were demonstrated (P < 0.05) in comparison with the saline-injected control group.

Conclusion: This result suggests variables that may need to be carefully considered to prevent BBB injury induced by nonionic CM for cerebral angiography, especially in the setting of a neurointerventional procedure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood-Brain Barrier / drug effects*
  • Carotid Arteries
  • Cerebral Angiography / methods*
  • Contrast Media / administration & dosage*
  • Contrast Media / pharmacology
  • Gadolinium DTPA
  • Injections, Intra-Arterial / methods
  • Iopamidol / administration & dosage*
  • Iopamidol / pharmacology
  • Magnetic Resonance Angiography / methods*
  • Male
  • Rabbits


  • Contrast Media
  • Iopamidol
  • Gadolinium DTPA