Evaluation of the role of nuclear factor-kappaB signaling in liver injury using genetic animal models

J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S43-6. doi: 10.1111/j.1440-1746.2006.04588.x.

Abstract

Most chronic liver diseases are not sufficiently treatable at present and very often progress to liver fibrosis and liver cirrhosis. Several recent studies have suggested that cytokines and cytokine-activated inflammatory signaling pathways might play an important role in the mediation of liver injury. Although pro-inflammatory signaling pathways such as nuclear factor (NF)-kappaB have evolved primarily for host defense to infections, they appear to be involved in the pathogenesis of inflammatory diseases and may mediate liver injury in response to a variety of agents and pathogens. Herein is summarized briefly some recent findings concerning the role of NF-kappaB in different models of liver injury based on transgenic and knockout animal technology.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Cytokines / immunology
  • Liver Diseases / immunology*
  • Mice
  • Mice, Knockout
  • Models, Animal
  • Models, Genetic
  • NF-kappa B / physiology*
  • Signal Transduction*

Substances

  • Cytokines
  • NF-kappa B