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doi: 10.1016/j.cell.2006.08.024.
Signaling by transmembrane proteins shifts gears
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- PMID: 16959559
- DOI: 10.1016/j.cell.2006.08.024
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Comment
Signaling by transmembrane proteins shifts gears
Cell.
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Free article
Abstract
The HAMP domain is present in a large number of transmembrane proteins in prokaryotes including histidine kinases, adenylyl cyclases, chemotaxis receptors, and phosphatases. In this issue of Cell, Hulko et al. (2006) report the NMR structure of a HAMP domain and present data suggesting that it transduces signals through a simple rotation of its four-helix parallel coiled coil.
Comment on
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The HAMP domain structure implies helix rotation in transmembrane signaling.Cell. 2006 Sep 8;126(5):929-40. doi: 10.1016/j.cell.2006.06.058. Cell. 2006. PMID: 16959572
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