Hodgkin's disease in children: correlation of clinical characteristics, staging procedures, and treatment at the University of Minnesota

Am J Pediatr Hematol Oncol. 1990 Summer;12(2):147-54.


The cases of 63 children treated for Hodgkin's disease were retrospectively evaluated according to clinical and laboratory characteristics at initial appearance, clinical and pathologic staging, and treatment for their effects on survival and disease-free survival. An initial erythrocyte sedimentation rate over 50 mm/h was common in patients who ultimately had a relapse. There was no correlation between the size of the mediastinal mass at diagnosis and occurrence of relapse. A residual mediastinal mass was found in 22% of patients after 1 year of treatment regardless of its size at initial appearance. With a median follow-up time of 10.5 years, the overall survival rate is 89%, and disease-free survival rate is 71%. The disease-free survival rates for patients with stages I-IV disease are 92, 81, 78, and 40%, respectively. Relapses occurred in 7 of 22 (36%) patients with positive staging laparotomy despite radiotherapy for three with stage IA and IIA disease, chemotherapy alone for two with stage IIIB disease, or chemotherapy for one with stage IIIB and one with stage IVB disease. Of patients who had no evidence of abdominal Hodgkin's disease at a staging laparotomy, 6 of 34 (19%) had a relapse. These included one with stage IA and five stage IIA disease, all treated with radiotherapy alone. Treatment of stage III and IV disease with regimens including CCNU (lomustine) or cyclophosphamide, plus vinblastine sulfate or vincristine sulfate, prednisone, and procarbazine hydrochloride with or without radiation therapy yielded poor results, with 6/7 having a relapse.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adolescent
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bleomycin / administration & dosage
  • Child
  • Child, Preschool
  • Combined Modality Therapy
  • Dacarbazine / administration & dosage
  • Doxorubicin / administration & dosage
  • Female
  • Hodgkin Disease / drug therapy
  • Hodgkin Disease / epidemiology*
  • Hodgkin Disease / pathology
  • Hodgkin Disease / radiotherapy
  • Humans
  • Lomustine / administration & dosage
  • Male
  • Mechlorethamine / administration & dosage
  • Minnesota / epidemiology
  • Neoplasm Staging
  • Prednisone / administration & dosage
  • Procarbazine / administration & dosage
  • Radiotherapy, High-Energy / adverse effects
  • Retrospective Studies
  • Survival Rate
  • Vinblastine / administration & dosage
  • Vincristine / administration & dosage


  • Bleomycin
  • Procarbazine
  • Mechlorethamine
  • Vincristine
  • Vinblastine
  • Lomustine
  • Dacarbazine
  • Doxorubicin
  • Prednisone

Supplementary concepts

  • ABVD protocol
  • CVPP protocol
  • MOPP protocol