Correlation between cardiac 123I-MIBG and odor identification in patients with Parkinson's disease and multiple system atrophy

Mov Disord. 2006 Nov;21(11):1975-7. doi: 10.1002/mds.21083.

Abstract

We investigated an association between olfaction and cardiac (123)I-metaiodobenzylguanidine (MIBG) uptake in patients with Parkinson's disease (PD) and multiple system atrophy (MSA). There was a significant positive correlation between cardiac MIBG uptake and the Cross-Cultural Smell Identification (CCSI) score in patients with PD (r = 0.56; P = 0.003) independent of the disease duration or clinical rating of motor status. However, patients with MSA did not show a significant correlation between cardiac MIBG uptake and the CCSI score. Our findings suggest that the functional losses of the olfactory and cardiac sympathetic systems are closely coupled in PD.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 3-Iodobenzylguanidine / chemistry*
  • Aged
  • Female
  • Heart / diagnostic imaging
  • Heart / drug effects
  • Humans
  • Male
  • Middle Aged
  • Multiple System Atrophy / diagnostic imaging
  • Multiple System Atrophy / physiopathology*
  • Odorants*
  • Parkinson Disease / diagnostic imaging
  • Parkinson Disease / physiopathology*
  • Radionuclide Imaging
  • Radiopharmaceuticals / chemistry*
  • Smell / drug effects
  • Smell / physiology*
  • Statistics as Topic

Substances

  • Radiopharmaceuticals
  • 3-Iodobenzylguanidine