Clinical aspects of parvovirus B19 infection

J Intern Med. 2006 Oct;260(4):285-304. doi: 10.1111/j.1365-2796.2006.01697.x.


Parvovirus B19 is a significant human pathogen that causes a wide spectrum of clinical complications ranging from mild, self-limiting erythema infectiosum in immunocompetent children to lethal cytopenias in immunocompromised patients and intrauterine foetal death in primary infected pregnant women. The infection may also be persistent and can mimic or trigger autoimmune inflammatory disorders. Another important clinical aspect to consider is the risk of infection through B19-contaminated blood products. Recent advances in diagnosis and pathogenesis, new insights in the cellular immune response and newly discovered genotypes of human parvoviruses form a platform for the development of modern therapeutic and prophylactic alternatives.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Autoimmune Diseases / immunology
  • Erythema Infectiosum / immunology
  • Erythrocytes / physiology
  • Female
  • Fetal Death / virology
  • Humans
  • Hydrops Fetalis / virology
  • Joint Diseases / immunology
  • Joint Diseases / virology
  • Parvoviridae Infections / diagnosis
  • Parvoviridae Infections / drug therapy
  • Parvoviridae Infections / immunology*
  • Parvovirus B19, Human / immunology*
  • Parvovirus B19, Human / physiology
  • Pregnancy
  • Pregnancy Complications, Infectious / virology
  • Tropism / immunology
  • Viral Vaccines / therapeutic use


  • Viral Vaccines