Expression of Fc epsilon R2/CD23 on peripheral blood macrophages/monocytes in Kawasaki disease

Clin Immunol Immunopathol. 1990 Aug;56(2):280-6. doi: 10.1016/0090-1229(90)90149-k.


We analyzed the expression of Fc epsilon R2/CD23 on peripheral blood macrophages/monocytes in 12 patients with Kawasaki disease (KD) using a fluorescence-activated cell sorter. The absolute counts of CD14+ macrophages/monocytes and CD23+ macrophages/monocytes were high, and were positively correlated during the acute stage of KD. These results indicate that the increased number of macrophages/monocytes during acute KD have the Fc epsilon R2/CD23 antigen present on the surface of the cells, suggesting that peripheral blood macrophages/monocytes have been activated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Antigens, CD / analysis*
  • Antigens, Differentiation, B-Lymphocyte / analysis*
  • Antigens, Differentiation, B-Lymphocyte / metabolism*
  • Antigens, Differentiation, Myelomonocytic / analysis
  • Flow Cytometry
  • Humans
  • Immunoglobulin E / metabolism
  • Lipopolysaccharide Receptors
  • Macrophage Activation
  • Macrophages / immunology*
  • Monocytes / immunology*
  • Mucocutaneous Lymph Node Syndrome / immunology*
  • Receptors, Fc / analysis*
  • Receptors, Fc / metabolism*
  • Receptors, IgE


  • Antigens, CD
  • Antigens, Differentiation, B-Lymphocyte
  • Antigens, Differentiation, Myelomonocytic
  • Lipopolysaccharide Receptors
  • Receptors, Fc
  • Receptors, IgE
  • Immunoglobulin E