PEDF: a potential molecular therapeutic target with multiple anti-cancer activities

Trends Mol Med. 2006 Oct;12(10):497-502. doi: 10.1016/j.molmed.2006.08.009. Epub 2006 Sep 7.


Pigment epithelium-derived factor (PEDF) is an endogenously produced protein that is widely expressed throughout the human body, and exhibits multiple and varied biological activities. Already established as a potent anti-angiogenic molecule, PEDF has recently shown promise as a potential anti-tumour agent, causing both direct and indirect tumour suppression. Here, we explore the unique anti-tumour properties of PEDF and discuss its role as an effective anti-angiogenic, anti-proliferative and pro-differentiation factor. We also discuss the prospects for PEDF therapy and the need for a closer evaluation of issues such as delivery, stability and potential toxicity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use*
  • Cell Proliferation / drug effects
  • Eye Proteins / therapeutic use*
  • Humans
  • Neoplasms / drug therapy*
  • Neovascularization, Pathologic / drug therapy
  • Nerve Growth Factors / therapeutic use*
  • Serpins / therapeutic use*


  • Angiogenesis Inhibitors
  • Eye Proteins
  • Nerve Growth Factors
  • Serpins
  • pigment epithelium-derived factor