Lymphatic mapping and sentinel node biopsy in women with high-risk endometrial cancer

Gynecol Oncol. 2007 Jan;104(1):100-3. doi: 10.1016/j.ygyno.2006.07.033. Epub 2006 Sep 11.


Objective: To evaluate fundal injection of blue dye and radiocolloid for lymphatic mapping and sentinel node identification in women with high-risk endometrial cancer.

Methods: At laparotomy, 18 women with high-risk endometrial cancer had isosulfan blue and technitium-99 radiocolloid injected into the uterine fundus subserosally. Sentinel nodes were then identified either by direct observation of blue dye, by radioactive counts using a handheld gamma counter, or by a combination of both methods. The number and location of sentinel node(s) were recorded and compared with the final lymph node specimens after hysterectomy and selective lymphadenectomy.

Results: A sentinel node was identified in only 8 (45%) of the cases. Four patients had sentinel nodes only in the pelvis, 2 had sentinel nodes in the pelvis and above the bifurcation of the aorta, and 2 patients had sentinel nodes above the bifurcation of the aorta only. Seven (88%) patients had unilateral drainage of dye and the radiocolloid; the other patient had bilateral drainage. No patients had metastatic disease to sentinel or nonsentinel lymph nodes.

Conclusions: Subserosal fundal injection of blue dye and the radiocolloid is a poor technique for identifying sentinel lymph nodes in patients with high-risk endometrial cancer.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Endometrial Neoplasms / diagnostic imaging
  • Endometrial Neoplasms / pathology*
  • Endometrial Neoplasms / surgery
  • Female
  • Humans
  • Lymph Nodes / diagnostic imaging
  • Lymph Nodes / pathology*
  • Lymph Nodes / surgery
  • Prospective Studies
  • Radionuclide Imaging
  • Sentinel Lymph Node Biopsy / methods*
  • Technetium Compounds


  • Technetium Compounds