Influence of long-term treatment with tuftsin analogue TP-7 on the anxiety-phobic states and body weight

Pharmacol Rep. Jul-Aug 2006;58(4):562-7.

Abstract

TP-7 is a synthetic analogue of tuftsin. It has a structure of tuftsin, to which three natural L-amino-acids Pro-Gly-Pro are attached. This heptapeptide improves learning and memorization and causes antidepressant and anxiolytic effect. It is possible to use TP-7 in the future to optimize cognitive functions and as a potential new anxioselective, fast-acting and easy-dosed drug. Therefore, it was purposeful to study such properties of the heptapeptide as its influence on anxiety-fear and body weight under a long-term treatment regimen. The experiment was performed on 24 preselected Wistar rats with the use of Rodina's method. There were three experimental groups of animals with high initial emotional reactivity: passive control group (P), active control group (A, receiving distilled water) and group treated with TP-7 at the dose of 0.3 mg/kg (T). The rats of A and T groups received intraperitoneal injections every day. The experiments were conducted 15 min after the administration of the drug, one and two days after initial testing day, then 1, 2, 3 and 4 weeks after that. The heptapeptide reduced the anxiety-phobic states significantly starting from the second day of drug application. The observed effects persisted throughout four weeks of the experiment, which confirmed effective long-term anxiolytic properties of the heptapeptide. TP-7 did not cause any changes in the body mass by itself.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Anxiety Agents / pharmacology*
  • Anti-Anxiety Agents / therapeutic use
  • Anxiety / drug therapy
  • Behavior, Animal / drug effects*
  • Body Weight / drug effects*
  • Fear / drug effects
  • Male
  • Motor Activity / drug effects
  • Oligopeptides / pharmacology*
  • Oligopeptides / therapeutic use
  • Phobic Disorders / drug therapy
  • Rats
  • Rats, Wistar
  • Reaction Time / drug effects
  • Time Factors
  • Tuftsin / analogs & derivatives
  • Tuftsin / pharmacology*
  • Tuftsin / therapeutic use

Substances

  • Anti-Anxiety Agents
  • Oligopeptides
  • Tuftsin
  • TP 7