Elevated KiSS-1 expression in the arcuate nucleus prior to the cyclic preovulatory gonadotrophin-releasing hormone/lutenising hormone surge in the ewe suggests a stimulatory role for kisspeptin in oestrogen-positive feedback

J Neuroendocrinol. 2006 Oct;18(10):806-9. doi: 10.1111/j.1365-2826.2006.01485.x.


Kisspeptins are encoded by the gene KiSS-1 and regulate gonadotrophin-releasing hormone (GnRH) and gonadotrophin secretion in various species, including humans. Here, we quantify gene expression of KiSS-1 in the arcuate nucleus (ARC) across the ovine oestrous cycle and demonstrate an increase in the caudal division of the ARC during the preovulatory period. These data strongly suggest that kisspeptins are involved in the generation of the preovulatory GnRH and luteinising hormone surge.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arcuate Nucleus of Hypothalamus / metabolism*
  • Estrous Cycle / metabolism
  • Estrous Cycle / physiology*
  • Feedback, Physiological
  • Female
  • Gene Expression Regulation
  • Gonadotropin-Releasing Hormone / metabolism
  • Gonadotropin-Releasing Hormone / physiology*
  • Luteinizing Hormone / metabolism
  • Luteinizing Hormone / physiology*
  • Ovulation / metabolism
  • Ovulation / physiology*
  • Progesterone / blood
  • Sheep


  • Gonadotropin-Releasing Hormone
  • Progesterone
  • Luteinizing Hormone