A novel autosomal dominant restless legs syndrome locus maps to chromosome 20p13

Neurology. 2006 Sep 12;67(5):900-1. doi: 10.1212/01.wnl.0000233991.20410.b6.


The authors investigated genetic factors contributing to restless legs syndrome (RLS) by performing a 10-cM genome-wide scan in a large French-Canadian pedigree. They detected an autosomal-dominant locus mapping to chromosome 20p13, with a maximum multipoint lod score of 3.86 at marker D20S849. This is the third reported autosomal-dominant locus for RLS and the first autosomal-dominant RLS locus in the French-Canadian population.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping / methods*
  • Chromosomes, Human, Pair 20*
  • Family Health*
  • Female
  • Genetic Linkage*
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Lod Score
  • Male
  • Restless Legs Syndrome / genetics*