Receptor-ligand-based specific cell adhesion on solid surfaces: hippocampal neuronal cells on bilinker functionalized glass

Nano Lett. 2006 Sep;6(9):1977-81. doi: 10.1021/nl061139w.


Cell adhesion through binding between specific cell membrane receptors and corresponding cell-adhesion-molecule (CAM)-coated solid surfaces is examined. The morphology of surfaces at various modification steps leading to functionalization with cell-binding CAMs is characterized. In one week neuron cultures, enhanced growth on surfaces modified with neuron-binding versus astrocyte-binding CAMs is observed. However, nonspecific adhesion on a poly-D-lysine-coated positive control surface is found to be even higher. Potential reasons and further studies needed are discussed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biomimetics / methods
  • Cell Adhesion / physiology
  • Cell Adhesion Molecules / chemistry*
  • Cell Adhesion Molecules / metabolism*
  • Cell Culture Techniques / methods*
  • Cells, Cultured
  • Coated Materials, Biocompatible / chemistry
  • Coated Materials, Biocompatible / pharmacology
  • Glass
  • Hippocampus / cytology*
  • Hippocampus / physiology*
  • Humans
  • Neurons / cytology*
  • Neurons / physiology*


  • Cell Adhesion Molecules
  • Coated Materials, Biocompatible