Extraintestinal manifestations of celiac disease

Curr Gastroenterol Rep. 2006 Oct;8(5):383-9. doi: 10.1007/s11894-006-0023-7.


Celiac disease is an autoimmune disorder that occurs in genetically predisposed individuals as the result of an immune response to gluten. It is present in approximately 1% of the population. Diarrhea has become a less common mode of presentation (<50% of cases) than it once was. Other presentations include iron-deficiency anemia, osteoporosis, dermatitis herpetiforme, and neurologic disorders, mainly peripheral neuropathy and ataxia. Arthritis is commonly found in patients with celiac disease when systematically sought. Overall, autoimmune diseases occur more frequently (three to ten times more) in those with celiac disease than in the general population. A gluten-free diet is the standard of treatment, although its effect on some of the extraintestinal manifestations remains to be determined.

Publication types

  • Review

MeSH terms

  • Anemia, Iron-Deficiency / etiology
  • Arthritis / etiology
  • Autoimmune Diseases / epidemiology
  • Celiac Disease / complications*
  • Celiac Disease / diagnosis
  • Celiac Disease / epidemiology
  • Celiac Disease / immunology
  • Comorbidity
  • Dermatitis Herpetiformis / etiology
  • Humans
  • Nervous System Diseases / etiology
  • Peripheral Nervous System Diseases / etiology