A follow-up study of road injury survivors admitted to hospital was conducted in the UK. The outcomes of road injury and their impact on quality of life were assessed using the SF-36v2, EQ-5D and CES-D scales. Lower extremity injury predominated (73%) in the study. Furthermore, there was a substantial impact on physical activity, large injury costs and potentially high QALY losses. Analysis of psychological effects found that females had higher levels of depression compared to males. This study identifies the consequences of road injury on individuals, highlighting the effective use of health outcome scales to quantify the quality of life changes over a 1-year period.