The BRCA1 E3 ubiquitin ligase controls centrosome dynamics

Cell Cycle. 2006 Sep;5(17):1946-50. doi: 10.4161/cc.5.17.3208. Epub 2006 Sep 1.

Abstract

The breast cancer specific tumor suppressor protein 1, BRCA1, mediates functions for all cells to grow. The puzzle of BRCA1 is that its loss is only associated with tumors in breast and ovarian epithelial cells. In this focused review, we highlight the data linking BRCA1 to the centrosome function, and we suggest that the specificity for breast tumors is due to a loss in restraint on centrosome function. Amplification of centrosome numbers secondary to loss of BRCA1 can drive the cell into the aneuploid state, thus, by this perspective loss of BRCA1 is a mutator phenotype.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • BRCA1 Protein / analysis
  • BRCA1 Protein / metabolism*
  • Breast Neoplasms / enzymology
  • Centrosome / enzymology*
  • Centrosome / physiology
  • Humans
  • Mice
  • Mitosis
  • Ubiquitin-Protein Ligases / analysis
  • Ubiquitin-Protein Ligases / metabolism*

Substances

  • BRCA1 Protein
  • Ubiquitin-Protein Ligases