A unified synthetic approach to the pyrazinone dragmacidins

Chem Commun (Camb). 2006 Sep 28:(36):3769-79. doi: 10.1039/b605929e. Epub 2006 Jul 18.

Abstract

This review describes recent developments from our laboratory involving the synthesis of the structurally complex, pyrazinone-containing dragmacidin alkaloids.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Combinatorial Chemistry Techniques
  • Drug Design*
  • Indole Alkaloids / chemical synthesis*
  • Indole Alkaloids / pharmacology*
  • Piperazines / chemical synthesis*
  • Piperazines / pharmacology*
  • Structure-Activity Relationship

Substances

  • Indole Alkaloids
  • Piperazines