Evidence for centrophenoxine as a protective drug in aluminium induced behavioral and biochemical alteration in rat brain

Mol Cell Biochem. 2006 Oct;290(1-2):33-42. doi: 10.1007/s11010-006-9125-7. Epub 2006 Sep 13.


Potential use of various nootropic drugs have been a burning area of research on account of various physical and chemical insult in brain under different toxicological conditions. One of the nootropic drug centrophenoxine, also known as an anti-aging drug has been exploited in the present experiment under aluminium toxic conditions. Aluminium was administered by oral gavage at a dose level of 100 mg/Kg x b x wt/day for a period of six weeks. To elucidate the region specific response, study was carried out in two different regions of brain namely cerebrum and cerebellum. Following aluminium exposure, a significant decrease in the activities of enzymes namely Hexokinase, Lactate dehydrogenase, Succinate dehydrogenase, Mg(2+) dependent ATPase was observed in both the regions. Moreover, the activity of acetylcholinesterase was also reported to be significantly decreased. Post-treatment with centrophenoxine was able to restore the altered enzyme activities and the effect was observed in both the regions of brain although the activity of lactate dehydrogenase and acetylcholinesterase did not register significant increase in the cerebellum region. Further, centrophenoxine was able to improve the altered short-term memory and cognitive performance resulted from aluminium exposure. From the present study, it can be concluded that centrophenoxine has a potential and can be exploited in other toxicological conditions also.

MeSH terms

  • Acetylcholinesterase / metabolism
  • Aluminum / pharmacology*
  • Animals
  • Behavior, Animal / drug effects*
  • Brain / physiopathology*
  • Ca(2+) Mg(2+)-ATPase / metabolism
  • Female
  • L-Lactate Dehydrogenase / metabolism
  • Meclofenoxate / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Succinate Dehydrogenase / metabolism


  • Meclofenoxate
  • Aluminum
  • L-Lactate Dehydrogenase
  • Succinate Dehydrogenase
  • Acetylcholinesterase
  • Ca(2+) Mg(2+)-ATPase