Genetic, ethnic, and gender differences in the pharmacokinetics of antiretroviral agents

Curr HIV/AIDS Rep. 2006 Sep;3(3):118-25. doi: 10.1007/BF02696655.

Abstract

Variable antiretroviral therapy (ART) drug response likely reflects the combined influence of environment, underlying disease, concurrent drugs, and genetics. Gender exerts modest or negligible effects on ART disposition, and it is expected to have limited clinical implication, although it should be accounted for in large population studies. Ethnic denominations have, with the notable exception of efavirenz, no clear influence on ART disposition. Exploration of genetic factors might offer a better comprehension to the largely unpredictable and unresolved variability in ART concentrations and related toxicity or treatment outcome. Despite the negative perception of genetic research among the general public, this type of investigation is now widely accepted by concerned parties: patients, relatives, and study volunteers.

Publication types

  • Review

MeSH terms

  • Anti-HIV Agents / pharmacokinetics*
  • Continental Population Groups
  • Ethnic Groups
  • Female
  • Genetic Variation
  • Humans
  • Male
  • Sex Characteristics

Substances

  • Anti-HIV Agents