Physiologic regulation of central and peripheral T cell tolerance: lessons for therapeutic applications

J Mol Med (Berl). 2006 Nov;84(11):887-99. doi: 10.1007/s00109-006-0098-5. Epub 2006 Sep 14.


Immunologic tolerance is a state of unresponsiveness that is specific for a particular antigen. The immune system has an extraordinary potential for making T cell and B cell that recognize and neutralize any chemical entity and microbe entering the body. Certainly, some of these T cells and B cells recognize self-components; therefore, cellular mechanisms have evolved to control the activity of these self-reactive cells and achieve immunological self-tolerance. The most important in vivo biological significance of mechanisms regulating self-tolerance is to prevent the immune system from mounting an attack against the host's own tissues resulting in autoimmunity. This review summarizes recent developments in our understanding of T-helper cell tolerance and discusses how the new findings can be exploited to prevent and treat autoimmune diseases, allergy, cancer, and chronic infection, or establish donor-specific transplantation tolerance.

Publication types

  • Review

MeSH terms

  • Adoptive Transfer*
  • Animals
  • Autoimmunity*
  • B-Lymphocytes / immunology
  • Clonal Anergy
  • Dendritic Cells / immunology
  • Graft Rejection / immunology
  • Graft Rejection / prevention & control
  • Hematopoietic Stem Cell Transplantation
  • Humans
  • Immune Tolerance*
  • Receptors, Antigen, T-Cell / immunology
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Helper-Inducer / immunology
  • T-Lymphocytes, Regulatory / immunology
  • Transplantation Tolerance


  • Receptors, Antigen, T-Cell