Amyotrophic lateral sclerosis as a complex genetic disease

Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):973-85. doi: 10.1016/j.bbadis.2006.08.001. Epub 2006 Aug 5.


In complex diseases like ALS, there are multiple genetic and environmental factors all contributing to disease liability. The genetic factors causing susceptibility to developing ALS can be considered a spectrum from single genes with large effect sizes causing classical Mendelian ALS, to genes of smaller effect, producing apparently sporadic disease. We examine the statistical genetic principles that underpin this model and review what is known about ALS as a disease with complex genetics.

Publication types

  • Review

MeSH terms

  • Age of Onset
  • Amyotrophic Lateral Sclerosis / epidemiology
  • Amyotrophic Lateral Sclerosis / genetics*
  • Animals
  • Gene Dosage
  • Genetic Predisposition to Disease*
  • Humans
  • Intermediate Filaments / genetics
  • Intermediate Filaments / metabolism
  • Mice
  • Mice, Transgenic
  • Mutation*
  • Neurons / metabolism
  • Superoxide Dismutase / genetics*
  • Superoxide Dismutase-1


  • SOD1 protein, human
  • Sod1 protein, mouse
  • Superoxide Dismutase
  • Superoxide Dismutase-1