Glutathione S transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population

Br J Ophthalmol. 2007 Apr;91(4):527-30. doi: 10.1136/bjo.2006.102418. Epub 2006 Sep 14.


Background: Genetic factors and oxidative damage have been shown to have a role in the development of primary open angle glaucoma (POAG).

Aim: To determine the effects of genetic polymorphisms of glutathione S transferase (GST)M1 and GSTT1 on the risk of POAG in a Turkish population.

Methods: Using a multiplex polymerase chain reaction (PCR), GSTM1 and GSTT1 gene polymorphisms were analysed in 144 patients with POAG and in 121 otherwise healthy controls of similar age.

Results: The GSTM1 positive genotype and the GSTT1 null genotype had an increased risk of developing POAG (p<0.001, OR 2.93, 95% CI 1.66 to 5.20 and OR 4.25, 95% CI 2.30 to 7.80, respectively). The risk of glaucoma also increased significantly in subjects with a combination of GSTM1 positive and GSTT1 null genotypes (p<0.001, OR 3.46, 95% CI 1.64 to 7.38).

Conclusion: The GSTM1 positive genotype and GSTT1 null genotype or the combination of both may be associated with the increased risk of development of POAG in the Turkish population.

MeSH terms

  • Aged
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease
  • Genotype
  • Glaucoma, Open-Angle / genetics*
  • Glutathione Transferase / genetics*
  • Humans
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Polymorphism, Genetic


  • glutathione S-transferase T1
  • Glutathione Transferase
  • glutathione S-transferase M1