Clinical evaluation of dietary modification for treatment of spontaneous chronic kidney disease in cats

J Am Vet Med Assoc. 2006 Sep 15;229(6):949-57. doi: 10.2460/javma.229.6.949.


Objective-To determine whether a renal diet modified in protein, phosphorus, sodium, and lipid content was superior to an adult maintenance diet in minimizing uremic episodes and mortality rate in cats with stage 2 or 3 chronic kidney disease (CKD). Design-Double-masked, randomized, controlled clinical trial. Animals-45 client-owned cats with spontaneous stage 2 or 3 CKD. Procedures-Cats were randomly assigned to an adult maintenance diet (n = 23 cats) or a renal diet (22) and evaluated trimonthly for up to 24 months. Efficacy of the renal diet, compared with the maintenance diet, in minimizing uremia, renal-related deaths, and all causes of death was evaluated. Results-Serum urea nitrogen concentrations were significantly lower and blood bicarbonate concentrations were significantly higher in the renal diet group at baseline and during the 12- and 24-month intervals. Significant differences were not detected in body weight; Hct; urine protein-to-creatinine ratio; and serum creatinine, potassium, calcium, and parathyroid hormone concentrations. A significantly greater percentage of cats fed the maintenance diet had uremic episodes (26%), compared with cats fed the renal diet (0%). A significant reduction in renal-related deaths but not all causes of death was detected in cats fed the renal diet. Conclusions and Clinical Relevance-The renal diet evaluated in this study was superior to an adult maintenance diet in minimizing uremic episodes and renalrelated deaths in cats with spontaneous stage 2 or 3 CKD.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Feed*
  • Animals
  • Blood Urea Nitrogen
  • Cat Diseases / diet therapy*
  • Cat Diseases / mortality
  • Cats
  • Diet, Protein-Restricted*
  • Disease Progression
  • Double-Blind Method
  • Female
  • Kidney Failure, Chronic / diet therapy
  • Kidney Failure, Chronic / mortality
  • Kidney Failure, Chronic / veterinary*
  • Longitudinal Studies
  • Male
  • Survival Analysis
  • Treatment Outcome
  • Uremia / prevention & control
  • Uremia / veterinary