DC-SIGN and immunoregulation

Cell Mol Immunol. 2006 Aug;3(4):279-83.


Dendritic cells (DCs) are known to be the most powerful professional antigen-presenting cells so far. It could activate primary immune response, and also downregulate immune response. DCs have a unique character of immunoregulation. DC-SIGN, a molecule designated as CD209, is one member of the C-type lectin superfamily. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. DC-SIGN has become hotspot of recent studies because of its important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. These studies on DC-SIGN involved in primary and secondary immune response and relevant mechanism will certainly provide us with a new method in treating and preventing certain diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Adhesion Molecules / chemistry
  • Cell Adhesion Molecules / physiology*
  • Dendritic Cells / immunology*
  • Humans
  • Immunity*
  • Lectins, C-Type / chemistry
  • Lectins, C-Type / physiology*
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / physiology*
  • Receptors, Pattern Recognition / immunology
  • Tumor Escape / immunology


  • Cell Adhesion Molecules
  • DC-specific ICAM-3 grabbing nonintegrin
  • Lectins, C-Type
  • Receptors, Cell Surface
  • Receptors, Pattern Recognition