Systemic administration of a dopamine, but not a serotonin or norepinephrine, transporter inhibitor reinstates cocaine seeking in the rat

Behav Brain Res. 2006 Nov 25;175(1):189-94. doi: 10.1016/j.bbr.2006.08.009. Epub 2006 Sep 15.


Reinstatement of cocaine-seeking behavior can be elicited by a systemic priming injection of cocaine or a non-selective biogenic amine transporter inhibitor. In order to determine which biogenic amine is responsible for this effect, selective dopamine (GBR 12909), serotonin (fluoxetine) or norepinephrine (nisoxetine) transporter inhibitors were systemically administered in order to assess their ability to induce cocaine seeking in rats. Administration of GBR 12909, but not nisoxetine or fluoxetine, dose-dependently reinstated cocaine seeking in rats. Furthermore, administration of the non-selective dopamine receptor antagonist flupenthixol into the nucleus accumbens shell attenuated GBR 12909-induced reinstatement of cocaine seeking. These results suggest that increases in extracellular concentrations of dopamine, specifically in the nucleus accumbens shell, are primarily responsible for promoting cocaine priming-induced reinstatement of drug seeking in rats.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Cocaine / administration & dosage
  • Cocaine-Related Disorders / drug therapy*
  • Cocaine-Related Disorders / psychology
  • Dopamine / administration & dosage*
  • Dose-Response Relationship, Drug
  • Drug Administration Routes
  • Drug Interactions
  • Enzyme Inhibitors / administration & dosage*
  • Male
  • Norepinephrine / administration & dosage*
  • Rats
  • Rats, Sprague-Dawley
  • Self Administration
  • Serotonin / administration & dosage*


  • Enzyme Inhibitors
  • Serotonin
  • Cocaine
  • Dopamine
  • Norepinephrine