Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors

Immunity. 2006 Sep;25(3):349-60. doi: 10.1016/j.immuni.2006.08.009.


Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation / immunology*
  • Humans
  • Interferon Regulatory Factors / physiology*
  • Interferon Type I / biosynthesis*
  • Interferon Type I / genetics*
  • Transcriptional Activation


  • Interferon Regulatory Factors
  • Interferon Type I