Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure

Wendy J Watkins; Alexandra J Umbers; Kathryn J Woad; Sarah E Harris; Ingrid M Winship; Ksenija Gersak; Andrew N Shelling

doi:10.1016/j.fertnstert.2006.03.054

Mutational screening of FOXO3A and FOXO1A in women with premature ovarian failure

Fertil Steril. 2006 Nov;86(5):1518-21. doi: 10.1016/j.fertnstert.2006.03.054. Epub 2006 Sep 18.

Authors

Wendy J Watkins¹, Alexandra J Umbers, Kathryn J Woad, Sarah E Harris, Ingrid M Winship, Ksenija Gersak, Andrew N Shelling

Affiliation

¹ Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

PMID: 16979636
DOI: 10.1016/j.fertnstert.2006.03.054

Abstract

FOXO3A and FOXO1A are excellent candidate genes for the development of premature ovarian failure and have not been analyzed previously in POF patients. Potentially causal mutations in FOXO3A (2/90; 2.2%) and FOXO1A (1/90; 1.1%) were identified in POF patients; however, the pathological role of these mutations will be determined only by screening increased numbers of patients and controls, or by functional studies.

Publication types

Controlled Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

DNA Mutational Analysis
Female
Forkhead Box Protein O1
Forkhead Box Protein O3
Forkhead Transcription Factors / genetics*
Genetic Predisposition to Disease / epidemiology
Genetic Predisposition to Disease / genetics
Genetic Testing / methods*
Humans
Mutation
New Zealand / epidemiology
Polymorphism, Single Nucleotide
Primary Ovarian Insufficiency / epidemiology*
Primary Ovarian Insufficiency / genetics*
Risk Assessment / methods*
Risk Factors
Slovenia / epidemiology

Substances

FOXO1 protein, human
FOXO3 protein, human
Forkhead Box Protein O1
Forkhead Box Protein O3
Forkhead Transcription Factors