Many gene and domain families have convergent fates following independent whole-genome duplication events in Arabidopsis, Oryza, Saccharomyces and Tetraodon

Trends Genet. 2006 Nov;22(11):597-602. doi: 10.1016/j.tig.2006.09.003. Epub 2006 Sep 18.


Genome duplication is potentially a good source of new genes, but such genes take time to evolve. We have found a group of "duplication-resistant" genes, which have undergone convergent restoration to singleton status following several independent genome duplications. Restoration of duplication-resistant genes to singleton status could be important to long-term survival of a polyploid lineage. Angiosperms show more frequent polyploidization and a higher degree of duplicate gene preservation than other paleopolyploids, making them well-suited to further study of duplication-resistant genes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Arabidopsis / genetics*
  • Evolution, Molecular
  • Gene Duplication*
  • Genes, Plant
  • Genome, Fungal
  • Oryza / genetics*
  • Polyploidy
  • Protein Structure, Tertiary
  • Saccharomyces / genetics*
  • Tetraodontiformes / genetics*