Effect of mycophenolate mofetil monotherapy on T-cell functions and inosine monophosphate dehydrogenase activity in patients undergoing a kidney transplantation

Transplant Proc. 2006 Sep;38(7):2292-4. doi: 10.1016/j.transproceed.2006.06.121.


The aim of this study was to assess the effects of 1 g of mycophenolate mofetil (MMF) on T-cell function and inosine monophosphate dehydrogenase (IMPDH) activity among patients undergoing kidney transplantation. Five patients undergoing renal transplantation from a living donor were enrolled in this study. Compared to baseline (before MMF intake), CD25 and CD71 expression were significantly decreased during the first hour following MMF intake. T-cell proliferation and IMPDH activity also decreased dramatically. Thereafter, all biomarker levels increased over time. At 4 hours, CD25 and CD71 levels, as well as IMPDH activity, returned to almost baseline values, whereas T-cell proliferation remained below baseline. Intracytoplasmic IL-2 expression remained unchanged after MMF ingestions. In conclusion, administration of 1 g of MMF was associated with a transient decrease in CD25 expression in addition to a temporary dramatic decrease in both T-cell proliferation and IMPDH activity.

MeSH terms

  • Antigens, CD / drug effects
  • Antigens, CD / genetics
  • Biomarkers
  • Humans
  • IMP Dehydrogenase / metabolism*
  • Immunosuppressive Agents / therapeutic use
  • Interleukin-2 Receptor alpha Subunit / drug effects
  • Interleukin-2 Receptor alpha Subunit / genetics
  • Kidney Transplantation / immunology
  • Kidney Transplantation / physiology*
  • Living Donors
  • Mycophenolic Acid / analogs & derivatives*
  • Mycophenolic Acid / therapeutic use
  • Receptors, Transferrin / drug effects
  • Receptors, Transferrin / genetics
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*


  • Antigens, CD
  • Biomarkers
  • CD71 antigen
  • Immunosuppressive Agents
  • Interleukin-2 Receptor alpha Subunit
  • Receptors, Transferrin
  • IMP Dehydrogenase
  • Mycophenolic Acid