Lactobacillus rhamnosus strain GG modulates intestinal absorption, fecal excretion, and toxicity of aflatoxin B(1) in rats

Appl Environ Microbiol. 2006 Nov;72(11):7398-400. doi: 10.1128/AEM.01348-06. Epub 2006 Sep 15.

Abstract

In this study, the modulation of aflatoxin B(1) (AFB(1)) uptake in rats by administration of the probiotic Lactobacillus rhamnosus GG was demonstrated. Fecal AFB(1) excretion in GG-treated rats was increased via bacterial AFB(1) binding. Furthermore, AFB(1)-associated growth faltering and liver injury were alleviated with GG treatment.

MeSH terms

  • Aflatoxin B1* / chemistry
  • Aflatoxin B1* / metabolism
  • Aflatoxin B1* / toxicity
  • Animals
  • Feces / chemistry
  • Intestinal Absorption / physiology*
  • Lactobacillus rhamnosus*
  • Probiotics / administration & dosage*
  • Rats
  • Rats, Wistar
  • Weight Gain

Substances

  • Aflatoxin B1