Correlation of dopamine release in the nucleus accumbens with masculine sexual behavior in rats

Brain Res. 1990 Jul 30;524(1):160-3. doi: 10.1016/0006-8993(90)90507-8.


Extracellular dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in the nucleus accumbens (N. Acc.) were measured by in vivo microdialysis during male sexual activity. DA and DOPAC were significantly increased during copulation, but not during mild tail pinch. These results are consistent with studies showing increases in N. Acc. DA associated with positively reinforcing environmental stimuli.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3,4-Dihydroxyphenylacetic Acid / metabolism
  • Animals
  • Copulation
  • Dopamine / metabolism*
  • Female
  • Hydroxyindoleacetic Acid / metabolism
  • Male
  • Nucleus Accumbens / physiology*
  • Rats
  • Septal Nuclei / physiology*
  • Sexual Behavior, Animal*


  • 3,4-Dihydroxyphenylacetic Acid
  • Hydroxyindoleacetic Acid
  • Dopamine