Neuronal RNA granules: movers and makers

Neuron. 2006 Sep 21;51(6):685-90. doi: 10.1016/j.neuron.2006.08.021.


RNA localization contributes to cell polarity and synaptic plasticity. Evidence will be discussed that RNA transport and local translation in neurons may be more intimately linked than originally thought. Second, neuronal RNA granules, originally defined as intermediates involved in mRNA transport, are much more diverse in their composition and functions than previously anticipated. We focus on three classes of RNA granules that include transport RNPs, stress granules, and P bodies and discuss their potential functions in RNA localization, microRNA-mediated translational regulation, and mRNA degradation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Neurons / metabolism*
  • Protein Biosynthesis / genetics
  • RNA / genetics
  • RNA / metabolism*
  • RNA Stability
  • RNA Transport
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism


  • RNA, Messenger
  • RNA