Selectin polymorphisms and perinatal morbidity in low-birthweight infants

Acta Paediatr. 2006 Oct;95(10):1213-7. doi: 10.1080/08035250600575404.


Background: Studies have shown an association between altered expression of selectins and premature birth, early sepsis and bronchopulmonary dysplasia.

Aim: To investigate the possible link between functional polymorphisms of the E-, P- and L-selectin genes and perinatal morbidity.

Methods: We compared the genotype distribution of the E-selectin Ser128Arg, P-selectin Thr715Pro and L-selectin Pro213Ser polymorphisms in 125 low-birthweight singleton infants with those of 156 healthy term neonates. We also analysed the association of genotype with risk of sepsis and bronchopulmonary dysplasia.

Results: We found no association between E-selectin or P-selectin polymorphisms and premature birth, nor did we find any association between E-selectin or P-selectin and early postnatal sepsis or bronchopulmonary dysplasia. Carriers of the 213Ser L-selectin allele were found to be more prevalent in low-birthweight infants, particularly in those with bronchopulmonary dysplasia. We found no association between the L-selectin polymorphism and early postnatal sepsis.

Conclusion: Our results underline the importance of L-selectin in perinatal pathology, but further studies are needed to evaluate the alteration of L-selectin levels in carriers of the 213Ser allele and their possible contribution to premature birth and bronchopulmonary dysplasia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bronchopulmonary Dysplasia / genetics
  • E-Selectin / genetics
  • Female
  • Genotype
  • Humans
  • Infant, Low Birth Weight / physiology*
  • Infant, Newborn
  • Infant, Premature / physiology*
  • L-Selectin / genetics
  • Male
  • Morbidity
  • P-Selectin / genetics
  • Polymorphism, Genetic*
  • Selectins / genetics*
  • Sepsis / genetics


  • E-Selectin
  • P-Selectin
  • Selectins
  • L-Selectin