Abstract
We studied the genetic organization of bla(ACC-1) in 14 isolates of Enterobacteriaceae from France, Tunisia, and Germany. In a common ancestor, ISEcp1 was likely involved in the mobilization of this gene from the Hafnia alvei chromosome to a plasmid. Other genetic events involving insertion sequences (particularly IS26), transposons (particularly Tn1696), or sulI-type integrons have occurred, leading to complex genetic environments.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Chromosomes, Bacterial / genetics
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Cross Infection / microbiology*
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DNA Transposable Elements / genetics
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Enterobacteriaceae / enzymology*
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Enterobacteriaceae / isolation & purification
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Enterobacteriaceae Infections / microbiology*
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Genes, Bacterial*
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Hafnia alvei / genetics
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Humans
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Integrons / genetics
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Molecular Sequence Data
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Open Reading Frames
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Plasmids / genetics
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beta-Lactamases / genetics*
Substances
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DNA Transposable Elements
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beta-Lactamases
Associated data
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GENBANK/AJ870922
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GENBANK/AJ870923
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GENBANK/AJ870924
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GENBANK/AJ870925
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GENBANK/AJ870926