Genetic environment of acquired bla(ACC-1) beta-lactamase gene in Enterobacteriaceae isolates

Antimicrob Agents Chemother. 2006 Dec;50(12):4177-81. doi: 10.1128/AAC.00619-06. Epub 2006 Sep 18.

Abstract

We studied the genetic organization of bla(ACC-1) in 14 isolates of Enterobacteriaceae from France, Tunisia, and Germany. In a common ancestor, ISEcp1 was likely involved in the mobilization of this gene from the Hafnia alvei chromosome to a plasmid. Other genetic events involving insertion sequences (particularly IS26), transposons (particularly Tn1696), or sulI-type integrons have occurred, leading to complex genetic environments.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Chromosomes, Bacterial / genetics
  • Cross Infection / microbiology*
  • DNA Transposable Elements / genetics
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / isolation & purification
  • Enterobacteriaceae Infections / microbiology*
  • Genes, Bacterial*
  • Hafnia alvei / genetics
  • Humans
  • Integrons / genetics
  • Molecular Sequence Data
  • Open Reading Frames
  • Plasmids / genetics
  • beta-Lactamases / genetics*

Substances

  • DNA Transposable Elements
  • beta-Lactamases

Associated data

  • GENBANK/AJ870922
  • GENBANK/AJ870923
  • GENBANK/AJ870924
  • GENBANK/AJ870925
  • GENBANK/AJ870926