Higher plasma docosahexaenoic acid is associated with reduced progression of coronary atherosclerosis in women with CAD

J Lipid Res. 2006 Dec;47(12):2814-9. doi: 10.1194/jlr.P600005-JLR200. Epub 2006 Sep 18.


Fish intake, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and in some cases alpha-linolenic acid (ALA) have been associated with reduced risk of cardiovascular events and death. The association between n-3 fatty acids in plasma lipids and the progression of coronary artery atherosclerosis was assessed among women with established coronary artery disease (CAD). A prospective cohort study involved postmenopausal women (n = 228) participating in the Estrogen Replacement and Atherosclerosis Trial. Quantitative coronary angiography was performed at baseline and after 3.2 +/- 0.6 (mean +/- SD) years. Women with plasma phospholipid (PL) DHA levels above the median, compared with below, exhibited less atherosclerosis progression, as expressed by decline in minimum coronary artery diameter (-0.04 +/- 0.02 and -0.10 +/- 0.02 mm, respectively; P = 0.007) or increase in percentage stenosis (1.34 +/- 0.76% and 3.75 +/- 0.74%, respectively; P = 0.006), and had fewer new lesions [2.0% (0.5-3.5%) of measured segments (95% confidence interval) and 4.2% (2.8-5.6%), respectively; P = 0.009] after adjustments for cardiovascular risk factors. Similar results were observed for DHA in the triglycerides (TGs). EPA and ALA in plasma lipids were not significantly associated with atherosclerosis progression. Consistent with higher reported fish intake, higher levels of plasma TG and PL DHA are associated with less progression of coronary atherosclerosis in postmenopausal women with CAD.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Animals
  • Cohort Studies
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / diet therapy
  • Coronary Artery Disease / etiology
  • Coronary Artery Disease / prevention & control*
  • Dietary Fats, Unsaturated / administration & dosage
  • Docosahexaenoic Acids / blood*
  • Double-Blind Method
  • Eicosapentaenoic Acid / blood
  • Female
  • Fishes
  • Humans
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Triglycerides / blood
  • alpha-Linolenic Acid / blood


  • Dietary Fats, Unsaturated
  • Triglycerides
  • alpha-Linolenic Acid
  • Docosahexaenoic Acids
  • Eicosapentaenoic Acid