Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer

Cancer Metastasis Rev. 2006 Sep;25(3):323-31. doi: 10.1007/s10555-006-9002-6.


It is well established that cancers affect differentiation of dendritic cells and promote systemic expansion of immune suppressive immature myeloid cells. This phenomenon may represent a mechanism of tumor escape from immune attack and could have significant impact on tumor progression. In this review we discuss the role of different tumor-derived factors, which were implicated in abnormal myeloid cell differentiation. The role of reactive oxygen species as well as JAK/STAT signaling in mechanisms of the effects of tumor-derived factors on myeloid cells is also discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cytokines / metabolism*
  • Humans
  • Janus Kinases / physiology
  • Macrophages / immunology
  • Mice
  • Myeloid Cells / cytology*
  • Myeloid Cells / immunology
  • Neoplasms / immunology*
  • STAT Transcription Factors / physiology
  • Tumor Escape*


  • Cytokines
  • STAT Transcription Factors
  • Janus Kinases