Convulsants induce interleukin-1 beta messenger RNA in rat brain

Biochem Biophys Res Commun. 1990 Sep 14;171(2):832-7. doi: 10.1016/0006-291x(90)91221-d.


The effects of systemic administration of kainic acid and pentylenetetrazol on interleukin-1 beta gene expression in the rat brain was studied. After the administration of kainic acid in a convulsive dose (10 mg/kg i.p.), Interleukin-1 beta mRNA was induced intensely in the cerebral cortex, thalamus and hypothalamus, moderately in the hippocampus and weakly in the striatum, but not in the midbrain, pons-medulla and cerebellum. Pentylenetetrazol induced Interleukin-1 beta mRNA in the cerebral cortex, hypothalamus, and hippocampus with a faster time-course than kainic acid. Diazepam suppressed both the convulsion and the induction of Interleukin-1 beta mRNA produced by kainic acid. Dexamethasone suppressed the induction of Interleukin-1 beta mRNA, but did neither the convulsion nor the induction of c-fos mRNA following the injection of kainic acid. These results provide the first evidence that intensive neuronal excitation induces Interleukin-1 beta mRNA in particular regions of the brain.

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / immunology*
  • Convulsants / pharmacology*
  • DNA / genetics
  • DNA / isolation & purification
  • Dexamethasone / pharmacology
  • Diazepam / pharmacology
  • Gene Expression / drug effects
  • Interleukin-1 / genetics*
  • Kainic Acid / pharmacology*
  • Kinetics
  • Male
  • Nucleic Acid Hybridization
  • Organ Specificity
  • Pentylenetetrazole / pharmacology*
  • RNA / genetics
  • RNA / isolation & purification
  • RNA, Messenger / drug effects
  • RNA, Messenger / genetics*
  • Rats
  • Rats, Inbred Strains


  • Convulsants
  • Interleukin-1
  • RNA, Messenger
  • RNA
  • Dexamethasone
  • DNA
  • Diazepam
  • Kainic Acid
  • Pentylenetetrazole