Sociotropy and autonomy are conceptualized as two personality dimensions that relate to an individual's vulnerability to depression. Sociotropy is characterized as an excessive investment in interpersonal relationships, and autonomy is characterized as an excessive concern with personal achievement and control. This study examined the relationships between sociotropy and autonomy, and a variety of interpersonal problems with close and nonclose others. Results suggested that sociotropic individuals are overly nurturant to nonclose others but vindictive to individuals who are close to them. In contrast, autonomous individuals were found to be domineering to nonclose others but socially avoidant toward people close to them. These findings are discussed in the context of recent research regarding the interpersonal patterns associated with sociotropy and autonomy.