Novel and efficient synthesis of iminocoumarins via copper-catalyzed multicomponent reaction

Sun-Liang Cui; Xu-Feng Lin; Yan-Guang Wang

doi:10.1021/ol061685w

Novel and efficient synthesis of iminocoumarins via copper-catalyzed multicomponent reaction

Org Lett. 2006 Sep 28;8(20):4517-20. doi: 10.1021/ol061685w.

Authors

Sun-Liang Cui¹, Xu-Feng Lin, Yan-Guang Wang

Affiliation

¹ Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China.

PMID: 16986939
DOI: 10.1021/ol061685w

Abstract

A variety of substituted iminocoumarins are prepared in good to excellent yields via a copper-catalyzed multicomponenet reaction of sulfonyl azides, terminal alkynes, and salicylaldehydes or o-hydroxylacetophenones. The method is general, mild, versatile, and efficient. A plausible mechanism for the domino process is proposed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Copper / chemistry*
Coumarins / chemical synthesis*
Coumarins / chemistry
Crystallography, X-Ray
Imines / chemistry*
Models, Molecular

Substances

Coumarins
Imines
Copper