Posttranslational modifications of NEMO and its partners in NF-kappaB signaling

Trends Cell Biol. 2006 Nov;16(11):569-77. doi: 10.1016/j.tcb.2006.09.004. Epub 2006 Sep 20.

Abstract

NEMO, the regulatory subunit of the IkappaB kinase (IKK) complex that controls the activation of the transcription factor NF-kappaB, is required for IKK function in most situations, but its exact mode of action has remained elusive until recently. A series of publications now provides information about how posttranscriptional modifications of NEMO, such as ubiquitination, sumoylation or phosphorylation, regulate its function in the IKK complex. These modifications might also regulate a cytosolic pool of free NEMO that controls the activation of NF-kappaB induced by genotoxic stress. Together with a better identification of the modifications controlling partners of NEMO, a clearer picture of how IKK becomes activated upon cell stimulation is starting to emerge, providing new clues for how the NF-kappaB pathway could be modulated for therapeutic purposes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • I-kappa B Kinase / metabolism*
  • NF-kappa B / metabolism*
  • Protein Processing, Post-Translational*
  • Signal Transduction
  • Stress, Physiological

Substances

  • IKBKG protein, human
  • NF-kappa B
  • I-kappa B Kinase