Planar cell polarity, ciliogenesis and neural tube defects

Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R227-34. doi: 10.1093/hmg/ddl216.

Abstract

Cilia are microtubule-based protrusions that are found on the surface of most vertebrate cells. Long studied by cell biologists, these organelles have recently caught the attention of developmental biologists and human geneticists. In this review, I will discuss recent findings suggesting a link between cilia and the planar cell polarity signaling cascade. In particular, I will focus on how this interaction may influence the process of neural tube closure and how these results may be relevant to our understanding of common human birth defects in which neural tube closure is compromised.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Polarity / genetics
  • Cell Polarity / physiology*
  • Cilia / physiology*
  • Humans
  • Models, Biological
  • Mutation
  • Neural Tube Defects / embryology
  • Neural Tube Defects / etiology*
  • Neural Tube Defects / genetics
  • Neural Tube Defects / physiopathology
  • Signal Transduction / genetics
  • Signal Transduction / physiology